Benzodiazepines were as safe as and more effective than placebo for out-of-hospital status epilepticus.
نویسنده
چکیده
Patients 205 patients (258 enrollments) who were >18 years of age (mean age 51 y, 63% men, 50% white) and had an out-of-hospital diagnosis of status epilepticus. Exclusion criteria included pulse < 60 beats/minute, systolic blood pressure < 100 mm Hg, and a history of long-term use of or sensitivity to benzodiazepines. Only data from the first enrollment of each patient was reported. {Follow-up was 100%.}†
منابع مشابه
A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus.
BACKGROUND It is uncertain whether the administration of benzodiazepines by paramedics is an effective and safe treatment for out-of-hospital status epilepticus. METHODS We conducted a randomized, double-blind trial to evaluate intravenous benzodiazepines administered by paramedics for the treatment of out-of-hospital status epilepticus. Adults with prolonged (lasting five minutes or more) or...
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Background & Aims Seizure is a chronic neurological disease and a disorder of the nervous system caused by severe and sudden electrical discharge of neural cells. Status epilepticus is defined as any generalized tonic-colonic seizures lasting more than 5 minutes, any focal seizures lasting more than 10 minutes, and recurrent seizures without returning to baseline between periods of seizures. Th...
متن کاملP-42: Protective Effects of Melatonin on The Testis in Post-Status Epilepticus Rats Following Lithium-Pilocarpin Injection As A Model of Temporal Lobe Epilepsy (TLE)
Background: Reproductive dysfunction and endocrine disorders are common among men with complex partial seizures of temporal lobe origin. More than 90% of men with epilepsy have abnormal semen analysis, including decreased sperm count, abnormal morphology, and impaired motility. The aim of this study was the assay of chronic treatment with melatonin during the latent phase and chronic phase of e...
متن کاملIntramuscular versus intravenous benzodiazepines for prehospital treatment of status epilepticus.
Acute seizures account for 1% of adult and 2% of pediatric emergency department visits, at an annual cost of $1 billion (in U.S. dollars).1 When seizures are prolonged or repetitive without recovery between episodes, the condition is termed status epilepticus, and it occurs in approximately 6% of visits to the emergency department for seizures. The cost for inpatient care of patients in status ...
متن کاملصرع پایدار مقاوم در کودکان، عوامل خطر، درمان و سرانجام زودرس
Introduction: Refractory status epilepticus is a life-threatening disease in children wherein seizure movements don't response to first line anti convulsion drugs. This study reviewed risk factors, management and early outcome of children with refractory status epilepticus. Methods: Patients with refractory status epilepticus admitted in Tabriz children's hospital between 2003 and 2006 were re...
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ورودعنوان ژورنال:
- ACP journal club
دوره 136 3 شماره
صفحات -
تاریخ انتشار 2002